對照置頂的OG48連結,我還是有很多疑問:(大概我實在太笨了)
1.第一段我大概了解他在說CAFFEINE會抑制腺甘酸的活動,而腺甘酸會降低腦細胞得的活動,然後CAFFEINE藉由阻止腺甘酸附著在細胞薄膜上來抑制腺甘酸,但是降低腦細胞活動量是什麼意思?是讓人清醒還是想睡覺?
2.For many years, caffeine’s effects have been attributed to its inhibition(抑制) of the production of phosphodiesterase(講述一個過去就被接受的因果關係，是因為一個叫P的酵素，這P可以分解AMP，讓AMP無法作用，但caffeine卻是壓抑P的作用), an enzyme that breaks down the chemical called cyclic AMP. A number of neurotransmitters exert their effects by first increasing cyclic AMP concentrations in target neurons(總結第二段前兩句，可以得出作者引述過去看法，認為AMP的升高可以使neutron更興奮). Therefore, prolonged periods at the elevated concentrations, as might be brought about by a phosphodiesterase inhibitor(只要AMP上升，P就會受壓抑), could lead to a greater amount of neuron firing and, consequently, to behavioral stimulation.
我看完這段做的筆記是"過去以來,咖啡因抑制P,而P會使AMP下降"但我不知道為什麼AMP上升,P就會受壓抑耶,不懂~因為我感覺P才是主要作用者
3.最後一段我看不出來它在承接什麼,更別提看出來它在承接上一段的T,這整段我就是一直不懂...雖然沒有生字,但是真的看不懂,也翻譯不出來,不知道有沒有閱讀強人可以翻譯這段,感激不盡,如下:
There were some apparent exceptions to the general correlation observed between adenosine-receptor binding and stimulation(承續第三段最後提出的Theophylline，但引出例外補充說明). One of these was a compound called3-isobuty1-1-methylxanthine(IBMX), which bound very well but actually depressed mouse locomotion. Snyder et al suggest that this is not a major stumbling block to their hypothesis(不會成為他們假設的障礙). The problem is that the compound has mixed effects in the brain, a not unusual occurrence with psychoactive drugs. Even caffeine, which is generally known only for its stimulatory effects, displays this property, depressing mouse locomotion at very low concentrations and stimulating it at higher ones.
唉~看這篇已經一小時,真的頓時沒自信到一個極致,萬一我考試遇到這種一直一直就是不懂的要怎麼辦阿
焦躁不安中~~~
,希望我這個小瓜呆不會讓妳太麻煩喔
,我要再去奇摩跟大家推!(昨天跟同學推囉^^)
